Data/hora: 01/06/2024 07:26:35

Provedor de dados: 	55	
País: 	Brazil	
Título: 	New therapy of pleural empyema by deoxyribonuclease	
Autores: 	Kacprzak,Grzegorz; Majewski,Andrzej; Kolodziej,Jerzy; Rzechonek,Adam; Gürlich,Robert; Bobek,Vladimir.	
Data: 	2013-02-01	
Ano: 	2013	
Palavras-chave: 	Empyema; Lung; Viscosity; Deoxyribonuclease.	
Resumo: 	Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics. Local management depends on patient general condition, but in all cases the essential procedure is to insert a drain into the pleural cavity and to evacuate the pus. Sometimes pus is very thick and its evacuation and following re-expansion of the lung is rather impossible. In these patients surgical intervention is needed. The use of intrapleural enzymes to support the drainage was first described in 1949 by Tillett and Sherry using a mixture of streptokinase and streptococcal deoxyribonuclease. Nowadays, purified streptokinase has come into widespread use, but recent studies reported no streptokinase effect on pus viscosity. On the other side, deoxyribonuclease reduces pus viscosity and may be more useful in treatment. We report two cases of intrapleural administration of Pulmozyme (alfa dornase - deoxyribonuclease (HOFFMANN-LA ROCHE AG) in dosage 2 × 2.5 mg with a significant improvement caused by changes in pus viscosity.	
Tipo: 	Info:eu-repo/semantics/report	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100015	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2012.08.019	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.17 n.1 2013	
Fonte: 	info:eu-repo/semantics/openAccess