Data/hora: 06/06/2024 13:05:44

Provedor de dados: | 55
País: | Brazil
Título: | Non-polarized cytokine profile of a long-term non-progressor HIV infected patient
Autores: | Pina,Ana Flávia; Matos,Vanessa Terezinha Gubert de; Bonin,Camila Mareti; Dal Fabbro,Márcia Maria Ferrairo Janini; Tozetti,Inês Aparecida.
Data: | 2018-03-01
Ano: | 2018
Palavras-chave: | Interleukins; HIV seropositivity; Disease progression; Antiretroviral therapy.
Resumo: | ABSTRACT The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200142
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2018.01.003
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.22 n.2 2018
Fonte: | info:eu-repo/semantics/openAccess