Data/hora: 03/06/2024 05:48:10

Provedor de dados: | 55
País: | Brazil
Título: | Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections
Autores: | Otting,Kristin A.; Stover,Kayla R.; Cleary,John D.
Data: | 2014-10-01
Ano: | 2014
Palavras-chave: | Piperacillin–tazobactam; Galactomannan; Beta-lactams; Drug interactiona.
Resumo: | Several studies have demonstrated that piperacillin/tazobactam produces a false-positive result for the galactomannan antigen test. However, the most recent literature has demonstrated that this interaction is no longer a concern. There is little information regarding the drug–laboratory interaction with the generics of piperacillin/tazobactam or other broad-spectrum beta-lactams, such as ceftaroline, doripenem, imipenem/cilastatin, and meropenem. The purpose of this study was to determine if a drug–laboratory interaction exists with these antibiotics. Tests showed that one lot of imipenem/cilastatin by Hospira Healthcare India Private Limited produced a false-positive result for the galactomannan antigen test. All other medications tested, including piperacillin/tazobactam from seven manufacturers and imipenem/cilastatin by Hospira Inc., did not produce positive results. Since the reason for this drug–laboratory interaction with imipenem/cilastatin is unknown, more studies are needed to further investigate this interaction. Providers also should be educated of these findings: no drug–laboratory interaction with piperacillin/tazobactam and a possible drug–laboratory interaction with imipenem/cilastatin (Hospira Healthcare India Private Limited).
Tipo: | Info:eu-repo/semantics/report
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500544
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2014.03.009
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.18 n.5 2014
Fonte: | info:eu-repo/semantics/openAccess