Data/hora: 11/06/2024 04:59:26

Provedor de dados: | 56
País: | Brazil
Título: | Serum antigliadin antibody levels as a screening criterion before jejunal biopsy indication for celiac disease in a developing country
Autores: | Bahia,M.; Rabello,A.; Brasileiro Filho,G.; Penna,F.J.
Data: | 2001-11-01
Ano: | 2001
Palavras-chave: | Celiac disease; Enteropathies; Antigliadin antibodies.
Resumo: | The objective of the present study was to determine the efficacy of detection of antigliadin immunoglobulins G and A (IgG and IgA) for the diagnosis of celiac disease in a developing country, since other enteropathies might alter the levels of these antibodies. Three groups were studied: 22 patients with celiac disease (mean age: 30.6 months), 61 patients with other enteropathies (mean age: 43.3 months), and 46 patients without enteropathies (mean age: 96.9 months). Antigliadin IgG and IgA ELISA showed sensitivity of 90.9 and 95.5%, respectively. With the hypothetical values of prevalence ranging from 1:500 to 1:2000 liveborns, the positive predictive value varied from 8.5 to 2.3% for IgG and from 4.8 to 1.1% for IgA. Considering the patients without enteropathies, specificity was 97.8 and 95.7% for IgG and IgA, respectively. In patients with other enteropathies, specificity was 82.0 and 84.1%, respectively. When patients with and without other enteropathies were considered as a whole, specificity was 88.8 and 91.6%, respectively. The specificity of positive IgG or IgA was 93.5% in children without enteropathies and 78.7% in the presence of other enteropathies. The negative predictive value for hypothetical prevalences varying from 1:500 to 1:2000 liveborns was 99.9%. Thus, even in developing countries where the prevalence of non-celiac enteropathies is high, the determination of serum antigliadin antibody levels is a useful screening test prior to the jejunal biopsy in the investigation of intestinal malabsorption.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100007
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2001001100007
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.34 n.11 2001
Fonte: | info:eu-repo/semantics/openAccess