Data/hora: 12/06/2024 02:11:23

Provedor de dados: | 56
País: | Brazil
Título: | Topographic abnormality of slow cortical potentials in schizophrenia
Autores: | Basile,L.F.H.; Yacubian,J.; Ferreira,B.L.C.; Valim,A.C.; Gattaz,W.F.
Data: | 2004-01-01
Ano: | 2004
Palavras-chave: | High-resolution EEG; Slow potentials; Contingent negative variations; Schizophrenia; Source localization; Functional brain mapping.
Resumo: | A recent study from our laboratory has provided evidence for the generation of slow potentials occurring in anticipation to task-performance feedback stimuli, in multiple association cortical areas, consistently including two prefrontal areas. In the present study, we intended to determine whether these slow potentials would indicate some abnormality (topographic) in schizophrenic patients, and thus serve as an indication of abnormal association cortex activity. We recorded slow potentials while subjects performed a paired-associates memory task. A 123-channel EEG montage and common average reference were used for 20 unmedicated schizophrenic (mean duration of illness: 11.3 ± 9.2 years; mean number of previous hospitalizations: 1.2 ± 1.9) and 22 healthy control subjects during a visual paired-associates matching task. For the topographic analysis, we used a simple index of individual topographic deviation from normality, corrected for absolute potential intensities. Slow potentials were observed in all subjects. Control subjects showed a simple spatial pattern of voltage extrema (left central positive and right prefrontal negative), whereas schizophrenic patients presented a more complex, fragmented pattern. Topographic deviation was significantly different between groups (P &lt; 0.001). The increased topographic complexity in schizophrenics could be visualized in grand averages computed across subjects. Increased topographic complexity could also be seen when grand averages were computed for subgroups of patients assembled either according to task-performance (high versus low) or by their scores on psychopathological scales. There was no significant correlation between topographic deviation and psychopathology scores. We conclude that the slow potential topographic abnormalities of schizophrenia indicate an abnormality in the configuration of large-scale electrical activity in association cortices.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100014
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2004000100014
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.37 n.1 2004
Fonte: | info:eu-repo/semantics/openAccess