Data/hora: 15/06/2024 18:19:36

Provedor de dados: | 56
País: | Brazil
Título: | Correlation between serum 25-hydroxyvitamin D levels and carotid intima-media thickness in a Brazilian population descended from African slaves
Autores: | Monteiro Júnior,F.C.; Mandarino,N.R.; Santos,E.M.; Santos,A.M.; Salgado,J.V.; Brito,D.J.A.; Salgado,B.J.L.; Lages,J.S.; Castelo Branco,G.; Salgado Filho,N.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Vitamin D deficiency; Carotid intima-media thickness (C-IMT); Atherosclerosis; African continental ancestry group.
Resumo: | Hypovitaminosis D has been identified as a possible new cardiovascular risk factor. However, the results of studies correlating serum vitamin D levels with markers of subclinical atherosclerosis have been conflicting. The aim of this study was to correlate serum levels of 25-hydroxyvitamin D [25(OH)D] with carotid intima-media thickness (C-IMT) and conventional cardiovascular risk factors in Afro-descendants. A cross-sectional analysis was performed on a sample of 382 individuals from a cohort of descendants of African slaves, inhabitants of “Quilombola” communities, with a mean age of 57.79 ±15.3 years, 54.5% of whom were women. Socio-demographic and clinical data were collected and biochemical tests were performed, including serum levels of 25(OH)D by electrochemiluminescence and urinary albumin excretion, evaluated by the albumin/creatinine ratio (ACR) in a spot urine sample. All participants underwent high-resolution ultrasonography for C-IMT measurement. Hypovitaminosis D was defined as serum 25(OH)D levels &lt;30 ng/mL. The mean serum 25(OH)D levels were 50.4±13.5 ng/mL, with a low prevalence of hypovitaminosis D (4.86%). By simple linear correlation, a significant inverse association between 25(OH)D levels and C-IMT (r=-0.174, P=0.001) was observed. However, after multiple linear regression analysis, the significance of the association between serum levels of 25(OH)D and C-IMT measurement was lost (β=-0.039, P=0.318) and only male gender, age, smoking, systolic blood pressure, glucose and low density lipoprotein (LDL)-cholesterol remained significantly associated with C-IMT. Levels of 25(OH)D were independently and positively associated with HDL-cholesterol and inversely associated with age and ACR. In conclusion, no independent association between 25(OH)D levels and C-IMT was observed in this population. On the other hand, there was an inverse association with albuminuria, a marker of endothelial lesion.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400606
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20177185
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.51 n.4 2018
Fonte: | info:eu-repo/semantics/openAccess