Data/hora: 07/06/2024 08:27:47

Provedor de dados: | 56
País: | Brazil
Título: | Vasorelaxant effects of the potassium channel opener SR 47063 on the isolated human saphenous vein and rat aorta
Autores: | Criddle,D.N.; de Moura,R.S.
Data: | 2000-08-01
Ano: | 2000
Palavras-chave: | SR 47063; K+-channel; Human saphenous vein; K ATP; Rat aorta; Levcromakalim; Glibenclamide.
Resumo: | The vasorelaxant effects of SR 47063 (4-(2-cyanimino-1,2-dihydropyrid-1-yl)-2,2-dimethyl-6-nitrochromene), a new K+-channel opener structurally related to levcromakalim, were examined in isolated human saphenous vein (HSV) and rat aorta (RA). HSV or RA rings were precontracted with either KCl or noradrenaline and cumulative relaxant concentration-response curves were obtained for SR 47063 (0.1 nM to 1 µM) in the presence or absence of 3 µM glibenclamide. SR 47063 potently relaxed HSV and RA precontracted with 20 mM (but not 60 mM) KCl or 10 µM noradrenaline in a concentration-dependent manner, showing slightly greater activity in the aorta. The potency of the effect of SR 47063 on HSV and RA was 12- and 58-fold greater, respectively, than that reported for the structurally related K+-channel opener levcromakalim. The vasorelaxant action of SR 47063 in both blood vessels was strongly inhibited by 3 µM glibenclamide, consistent with a mechanism of action involving ATP-dependent K+-channels.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000800013
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000800013
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.8 2000
Fonte: | info:eu-repo/semantics/openAccess