Data/hora: 01/06/2024 06:24:58

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Interleukin-15 as a potential regulator of the innate immune response	
Autores: 	Carson,W.; Caligiuri,M.A.	
Data: 	1998-01-01	
Ano: 	1998	
Palavras-chave: 	Interleukin-15; Interleukin-12; Gamma interferon; Natural killer cell; Innate immunity.	
Resumo: 	Interleukin-15 (IL-15) is a newly-discovered cytokine that is produced by activated monocytes early in the course of the innate immune response. IL-15 is able to bind to components of the interleukin-2 receptor (IL-2R) despite the fact that it has no sequence homology with IL-2. IL-15 stimulates human natural killer cell proliferation, cytotoxicity, and cytokine production and can substitute for IL-2 under most conditions. In vitro studies indicate that monocyte-derived IL-15 may be an important determinant of IFN-gamma production by NK cells. In addition, IL-15 is able to promote the survival of natural killer cells under serum-free conditions. The IL-15 receptor is a heterotrimeric complex which is composed of the IL-2Rß and &lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; chains in combination with a unique alpha chain (IL-15&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;). The IL-15R&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt; chain has strong sequence homology to the IL-2R&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt; chain and confers high affinity binding to the IL-15R. In contrast to IL-2, transcript for IL-15 and IL-15&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt; is expressed in a number of tissues and indicates that IL-15 may be an important ligand for cells that express components of the IL-2R	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100001	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X1998000100001	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.31 n.1 1998	
Fonte: 	info:eu-repo/semantics/openAccess