Data/hora: 06/06/2024 01:01:05

Provedor de dados: | 56
País: | Brazil
Título: | Cardiovascular actions of angiotensin-(1-7)
Autores: | Ferreira,A.J.; Santos,R.A.S.
Data: | 2005-04-01
Ano: | 2005
Palavras-chave: | Angiotensin-(1-7) receptor Mas; Renin-angiotensin system; Cardiac function; Blood vessels; Angiotensin-converting enzyme 2; Transgenic models.
Resumo: | Angiotensin-(1-7) (Ang-(1-7)) is now considered to be a biologically active member of the renin-angiotensin system. The functions of Ang-(1-7) are often opposite to those attributed to the main effector component of the renin-angiotensin system, Ang II. Chronic administration of angiotensin-converting enzyme inhibitors (ACEI) increases 10- to 25-fold the plasma levels of this peptide, suggesting that part of the beneficial effects of ACEI could be mediated by Ang-(1-7). Ang-(1-7) can be formed from Ang II or directly from Ang I. Other enzymatic pathways for Ang-(1-7) generation have been recently described involving the novel ACE homologue ACE2. This enzyme can form Ang-(1-7) from Ang II or less efficiently by the hydrolysis of Ang I to Ang-(1-9) with subsequent Ang-(1-7) formation. The biological relevance of Ang-(1-7) has been recently reinforced by the identification of its receptor, the G-protein-coupled receptor Mas. Heart and blood vessels are important targets for the formation and actions of Ang-(1-7). In this review we will discuss recent findings concerning the biological role of Ang-(1-7) in the heart and blood vessels, taking into account aspects related to its formation and effects on these tissues. In addition, we will discuss the potential of Ang-(1-7) and its receptor as a target for the development of new cardiovascular drugs.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400003
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2005000400003
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.38 n.4 2005
Fonte: | info:eu-repo/semantics/openAccess