Data/hora: 06/06/2024 02:17:52

Provedor de dados: | 56
País: | Brazil
Título: | Does acute hyperglycemia alter rat aortic depressor nerve function?
Autores: | Huber,D.A.; Carmo,J.M. do; Castania,J.A.; Fazan Jr,R.; Salgado,H.C.
Data: | 2007-11-01
Ano: | 2007
Palavras-chave: | Pressoreceptors; Hyperglycemia; Arterial pressure; Spectral analysis.
Resumo: | Because it is not known where in the reflex arch, i.e., afference, central nervous system or efferences, hyperglycemia affects baroreflex function, the present study examined the effect of short-term (30 min) hyperglycemia on aortic depressor nerve function measured by a mean arterial pressure vs aortic depressor nerve activity curve, fitted by sigmoidal regression, or by cross-spectral analysis between mean arterial pressure and aortic depressor nerve activity. Anesthetized male Wistar rats received an intravenous bolus (0.25 mL) injection, followed by 30 min of infusion (1 mL/h) of 30% glucose (N = 14). Control groups received a bolus injection and infusion of 0.9% saline (N = 14), or 30% mannitol (N = 14). Glucose significantly increased both blood glucose and plasma osmolarity (P &lt; 0.05). Mean arterial pressure did not change after glucose, saline or mannitol infusion. Mean arterial pressure vs nerve activity curves were identical before and 10 and 30 min after the beginning of glucose, saline or mannitol infusion. Slow (0.3 Hz) oscillations of arterial pressure were induced by controlled bleeding, and cross-spectral analysis was applied to arterial pressure and aortic nerve activity. Transfer function magnitude (aortic depressor nerve activity/mean arterial pressure ratio in the frequency domain) was calculated as an index of gain of the aortic depressor nerve. Transfer function magnitude was similar in all groups during induced or spontaneous oscillations of arterial pressure. In conclusion, the present study demonstrates, by means of two different approaches for assessing baroreceptor function, that aortic depressor nerve activity was not altered by short-term (30 min) hyperglycemia.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100017
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2007001100017
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.40 n.11 2007
Fonte: | info:eu-repo/semantics/openAccess