Data/hora: 06/06/2024 07:54:11

Provedor de dados: | 56
País: | Brazil
Título: | Association between the c.910A&amp;gt;G genetic variant of the XRCC1 gene and susceptibility to esophageal cancer in the Chinese Han population
Autores: | Chen,X.Q.; Wang,F.; Zheng,Y.L.; Fan,Q.X.; Yue,D.L.; Ma,Z.J.
Data: | 2013-12-01
Ano: | 2013
Palavras-chave: | Esophageal cancer; XRCC1 gene; Genetic variant; Molecular marker; Susceptibility.
Resumo: | Esophageal cancer (EC) is a common malignancy worldwide. The X-ray repair cross-complementing 1 gene (XRCC1) is one of the most important candidate genes for influencing susceptibility to EC. This study aimed to investigate the effect of XRCC1 genetic variants on susceptibility to EC. A total of 383 EC patients (males: 239, females: 144, mean age: 56.62) and 387 cancer-free controls (males: 251, females: 136, mean age: 58.23) were enrolled in this study. The c.910A&gt;G genetic variant of theXRCC1 gene was determined by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. The allele and genotype frequencies indicated statistical differences between EC patients and cancer-free controls. The c.910A&gt;G genetic variant was statistically associated with increased susceptibility to EC [GGvs AA: odds ratio (OR)=1.79, 95% confidence interval (CI)=1.12-2.86, P=0.014; GG vs AG/AA: OR=1.76, 95%CI=1.13-2.75, P=0.013; G vs A: OR=1.25, 95%CI=1.01-1.55, P=0.041]. The allele G and genotype GG could contribute to the increased susceptibility to EC. Our findings suggest that the c.910A&gt;G genetic variant is associated with susceptibility to EC in the Chinese Han population, and might be used as a molecular marker for detecting susceptibility to EC.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001201028
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20133396
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.46 n.12 2013
Fonte: | info:eu-repo/semantics/openAccess