Data/hora: 07/06/2024 10:00:40

Provedor de dados: | 56
País: | Brazil
Título: | Expression of extracellular matrix components and their receptors in the central nervous system during experimental Toxoplasma gondii and Trypanosoma cruzi infection
Autores: | Silva,A.A.; Roffê,E.; Lannes-Vieira,J.
Data: | 1999-05-01
Ano: | 1999
Palavras-chave: | Toxoplasma gondii; Trypanosoma cruzi; Central nervous system; Extracellular matrix.
Resumo: | Alterations in extracellular matrix (ECM) expression in the central nervous system (CNS) usually associated with inflammatory lesions have been described in several pathological situations including neuroblastoma and demyelinating diseases. The participation of fibronectin (FN) and its receptor, the VLA-4 molecule, in the migration of inflammatory cells into the CNS has been proposed. In Trypanosoma cruzi infection encephalitis occurs during the acute phase, whereas in Toxoplasma infection encephalitis is a chronic persisting process. In immunocompromised individuals such as AIDS patients, T. cruzi or T. gondii infection can lead to severe CNS damage. At the moment, there are no data available regarding the molecules involved in the entrance of inflammatory cells into the CNS during parasitic encephalitis. Herein, we characterized the expression of the ECM components FN and laminin (LN) and their receptors in the CNS of T. gondii- and T. cruzi-infected mice. An increased expression of FN and LN was detected in the meninges, leptomeninges, choroid plexus and basal lamina of blood vessels. A fine FN network was observed involving T. gondii-free and T. gondii-containing inflammatory infiltrates. Moreover, perivascular spaces presenting a FN-containing filamentous network filled with &lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;4+ and &lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;5+ cells were observed. Although an increased expression of LN was detected in the basal lamina of blood vessels, the CNS inflammatory cells were &lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;6-negative. Taken together, our results suggest that FN and its receptors VLA-4 and VLA-5 might be involved in the entrance, migration and retention of inflammatory cells into the CNS during parasitic infections.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500013
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1999000500013
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.32 n.5 1999
Fonte: | info:eu-repo/semantics/openAccess