Data/hora: 07/06/2024 00:47:36

Provedor de dados: | 56
País: | Brazil
Título: | Triorganotin as a compound with potential reproductive toxicity in mammals
Autores: | Delgado Filho,V.S.; Lopes,P.F.I.; Podratz,P.L.; Graceli,J.B.
Data: | 2011-09-01
Ano: | 2011
Palavras-chave: | Tributyltin; Triphenyltin; Endocrine disruptor; Aromatase; Imposex; Mammalian reproductive organs.
Resumo: | Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2011007500110
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.44 n.9 2011
Fonte: | info:eu-repo/semantics/openAccess