Data/hora: 06/06/2024 01:26:34

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Heterotopic transplantation of glycerin-preserved trachea: effect of respiratory epithelium desquamation on acute rejection	
Autores: 	Saueressig,M.G.; Edelweiss,M.I.A.; Souza,F.H.; Moreschi,A.H.; Savegnago,F.L.; Macedo Neto,A.V.	
Data: 	2005-07-01	
Ano: 	2005	
Palavras-chave: 	Graft rejection; Trachea; Transplantation; Glycerol; Respiratory mucosa.	
Resumo: 	An effective preservation method and decreased rejection are essential for tracheal transplantation in the reconstruction of large airway defects. Our objective in the present study was to evaluate the antigenic properties of glycerin-preserved tracheal segments. Sixty-one tracheal segments (2.4 to 3.1 cm) were divided into three groups: autograft (N = 21), fresh allograft (N = 18) and glycerin-preserved allograft (N = 22). Two segments from different groups were implanted into the greater omentum of dogs (N = 31). After 28 days, the segments were harvested and analyzed for mononuclear infiltration score and for the presence of respiratory epithelium. The fresh allograft group presented the highest score for mononuclear infiltration (1.78 ± 0.43, P &lt;= 0.001) when compared to the autograft and glycerin-preserved allograft groups. In contrast to the regenerated epithelium observed in autograft segments, all fresh allografts and glycerin-preserved allografts had desquamation of the respiratory mucosa. The low antigenicity observed in glycerin segments was probably the result of denudation of the respiratory epithelium and perhaps due to the decrease of major histocompatibility complex class II antigens.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700010	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2005000700010	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.38 n.7 2005	
Fonte: 	info:eu-repo/semantics/openAccess