Data/hora: 01/06/2024 00:49:56

Provedor de dados: | 56
País: | Brazil
Título: | Regulation of the kinin receptors after induction of myocardial infarction: a mini-review
Autores: | Tschöpe,C.; Heringer-Walther,S.; Walther,T.
Data: | 2000-06-01
Ano: | 2000
Palavras-chave: | B1 receptor; B2 receptor; Bradykinin; Heart infarction; Kallikrein-kinin system.
Resumo: | It is well known that the responses to vasoactive kinin peptides are mediated through the activation of two receptors termed bradykinin receptor B1 (B1R) and B2 (B2R). The physiologically prominent B2R subtype has certainly been the subject of more intensive efforts in structure-function studies and physiological investigations. However, the B1R activated by a class of kinin metabolites has emerged as an important subject of investigation within the study of the kallikrein-kinin system (KKS). Its inducible character under stress and tissue injury is therefore a field of major interest. Although the KKS has been associated with cardiovascular regulation since its discovery at the beginning of the last century, less is known about the B1R and B2R regulation in cardiovascular diseases like hypertension, myocardial infarction (MI) and their complications. This mini-review will summarize our findings on B1R and B2R regulation after induction of MI using a rat model. We will develop the hypothesis that differences in the expression of these receptors may be associated with a dual pathway of the KKS in the complex mechanisms of myocardial remodeling.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000600011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.6 2000
Fonte: | info:eu-repo/semantics/openAccess