Data/hora: 05/06/2024 13:21:25

Provedor de dados: | 56
País: | Brazil
Título: | Chronic granulomatous disease: why an inflammatory disease?
Autores: | Roxo-Junior,P.; Simão,H.M.L.
Data: | 2014-11-01
Ano: | 2014
Palavras-chave: | Chronic granulomatous disease; Inflammation; Infection; Granulomas; NADPH oxidase.
Resumo: | Chronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions. Among the latter, inflammatory manifestations are predominant, especially granulomas and colitis. In this article, we systematically review the possible mechanisms of hyperinflammation in this rare primary immunodeficiency condition and their correlations with clinical aspects.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100924
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20143735
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.47 n.11 2014
Fonte: | info:eu-repo/semantics/openAccess