Data/hora: 05/06/2024 06:31:08

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Chronic granulomatous disease: why an inflammatory disease?	
Autores: 	Roxo-Junior,P.; Simão,H.M.L.	
Data: 	2014-11-01	
Ano: 	2014	
Palavras-chave: 	Chronic granulomatous disease; Inflammation; Infection; Granulomas; NADPH oxidase.	
Resumo: 	Chronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions. Among the latter, inflammatory manifestations are predominant, especially granulomas and colitis. In this article, we systematically review the possible mechanisms of hyperinflammation in this rare primary immunodeficiency condition and their correlations with clinical aspects.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100924	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/1414-431X20143735	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.47 n.11 2014	
Fonte: 	info:eu-repo/semantics/openAccess