Data/hora: 07/06/2024 06:37:45

Provedor de dados: | 56
País: | Brazil
Título: | Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
Autores: | Weng,K.-G.; Yuan,Y.-L.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | Coumarin; X-ray; Lung cancer.
Resumo: | Series of novel coumarin derivatives [I (a–d) and II (a–d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100603
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20176455
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.50 n.11 2017
Fonte: | info:eu-repo/semantics/openAccess