Data/hora: 02/06/2024 16:28:44

Provedor de dados: | 56
País: | Brazil
Título: | Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model
Autores: | Callejas,G.H.; Figueira,R.L.; Gonçalves,F.L.L.; Volpe,F.A.P.; Zuardi,A.W.; Crippa,J.A.; Hallak,J.E.; Sbragia,L.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Gastroschisis; Experimental model; Prenatal treatment; Cannabidiol.
Resumo: | Gastroschisis (GS) is an abdominal wall defect that results in histological and morphological changes leading to intestinal motility perturbation and impaired absorption of nutrients. Due to its anti-inflammatory, antioxidant, and neuroprotective effects, cannabidiol (CBD) has been used as a therapeutic agent in many diseases. Our aim was to test the effect of maternal CBD in the intestine of an experimental model of GS. Pregnant rats were treated over 3 days with CBD (30 mg/kg) after the surgical induction of GS (day 18.5 of gestation) and compared to controls. Fetuses were divided into 4 groups: 1) control (C); 2) C+CBD (CCBD); 3) gastroschisis (G), and 4) G+CBD (GCBD). On day 21.5 of gestation, the fetuses were harvested and evaluated for: a) body weight (BW), intestinal weight (IW), and IW/BW ratio; b) histometric analysis of the intestinal wall; c) immunohistochemically analysis of inflammation (iNOS) and nitrite/nitrate level. BW: GCBD was lower than CCBD (P&lt;0.005), IW and IW/BW ratio: GCBD was smaller than G (P&lt;0.005), GCBD presented lower thickness in all parameters compared to G (P&lt;0.005), iNOS and nitrite/nitrate were lower concentration in GCBD than to G (P&lt;0.005). Maternal use of CBD had a beneficial effect on the intestinal loops of GS with decreased nitrite/nitrate and iNOS expression.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500607
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20177132
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.51 n.5 2018
Fonte: | info:eu-repo/semantics/openAccess