Data/hora: 08/06/2024 09:34:36

Provedor de dados: | 56
País: | Brazil
Título: | Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum
Autores: | Noël,F.; Geurts,M.; Maloteaux,J.-M.
Data: | 2000-02-01
Ano: | 2000
Palavras-chave: | Ryanodine; Striatum; 6-hydroxydopamine; Dopamine neurons; Neuroleptic malignant syndrome.
Resumo: | Dopamine nigrostriatal neurons are important for motor control and may contain a particularly dense population of ryanodine receptors involved in the control of dopamine release. To test this hypothesis, we used a classical model of unilateral selective lesion of these neurons in rats based on 6-hydroxydopamine (6-OHDA) injection into the substantia nigra. Binding of [3H]-GBR 12935, used as a presynaptic marker since it labels specifically the dopamine uptake complex, was dramatically decreased by 83-100% in striatum homogenates after 6-OHDA lesion. On the contrary, no reduction of [3H]-ryanodine binding was observed. The present data indicate that [3H]-ryanodine binding sites present in rat striatum are not preferentially localized in dopaminergic terminals.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200013
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000200013
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.2 2000
Fonte: | info:eu-repo/semantics/openAccess