Data/hora: 06/06/2024 03:45:27

Provedor de dados: | 56
País: | Brazil
Título: | Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia
Autores: | Teixeira,R.S.; Arriaga,M.B.; Terse-Ramos,R.; Ferreira,T.A.; Machado,V.R.; Rissatto-Lago,M.R.; Silveira-Mattos,P.S.; Boa-Sorte,N.; Ladeia,A.M.T.; Andrade,B.B.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | Sickle cell disease; Lipoproteins; Cholesterol; Triglycerides; Hydroxyurea; Endothelial function.
Resumo: | Dyslipidemia has been described in sickle cell anemia (SCA) but its association with increased disease severity is unknown. Here, we examined 55 children and adolescents with SCA as well as 41 healthy controls to test the association between the lipid profiles in peripheral blood and markers of hemolysis, inflammation, endothelial function, and SCA-related clinical outcomes. SCA patients exhibited lower levels of total cholesterol (P&lt;0.001), low-density lipoprotein cholesterol (LDL-c) (P&lt;0.001), and high-density lipoprotein cholesterol (HDL-c) (P&lt;0.001), while displaying higher triglyceride (TG) levels and TG/HDL-c ratio values (P&lt;0.001). TG/HDL-c values were positively correlated with lactate dehydrogenase (P=0.047), leukocyte count (P=0.006), and blood flow velocity in the right (P=0.02) and left (P=0.05) cerebral artery, while being negatively correlated with hemoglobin levels (P&lt;0.04). Acute chest syndrome (ACS) and vaso-occlusive events (VOE) were more frequent in SCA patients exhibiting higher TG/HDL-c values (odds ratio: 3.77, P=0.027). Multivariate logistic regression analysis confirmed independent associations between elevated TG/HDL-c values and SCA. Thus, children and adolescents with SCA exhibited a lipid profile associated with hemolysis and inflammatory parameters, with increased risk of ACS and VOE. TG/HDL-c is a potential biomarker of severity of disease.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000612
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20198833
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.52 n.10 2019
Fonte: | info:eu-repo/semantics/openAccess