Data/hora: 06/06/2024 01:26:37

Provedor de dados: | 56
País: | Brazil
Título: | Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease
Autores: | DosReis,G.A.
Data: | 2011-02-01
Ano: | 2011
Palavras-chave: | Trypanosoma cruzi; T cells; GPI-anchors; TGF-β; Mucin; Apoptosis.
Resumo: | Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensively and release immunomodulatory molecules that delay parasite-specific responses mediated by T cells. This immune evasion allows the parasite to spread in the host. In the chronic phase, parasite evasion relies on its replication strategy of hijacking the TGF-β signaling pathway involved in inflammation and tissue regeneration. In this article, the mechanisms of immune evasion described for T. cruzi are reviewed.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2011007500005
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.44 n.2 2011
Fonte: | info:eu-repo/semantics/openAccess