Data/hora: 11/06/2024 11:23:49

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility	
Autores: 	Wu,B.W.; Zhu,J.; Shi,H.M.; Jin,B.; Wen,Z.C.	
Data: 	2017-01-01	
Ano: 	2017	
Palavras-chave: 	Toll-like receptor 4; Polymorphism; Coronary heart disease; Meta-analysis.	
Resumo: 	Published data on the association between Toll-like receptor 4 (TLR4) Asp299Gly polymorphism and coronary heart disease (CHD) susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. English-language studies were identified by searching PubMed and Embase databases (up to November 2016). All epidemiological studies were regarding Caucasians because no TLR4 Asp/Gly and Gly/Gly genotypes have been detected in Asians. A total of 20 case-control studies involving 14,416 cases and 10,764 controls were included in the meta-analysis. Overall, no significant associations were found between TLR4 Asp299Gly polymorphism and CHD susceptibility in the dominant model (OR=0.89; 95%CI=0.74 to 1.06; P=0.20) pooled in the meta-analysis. In the subgroup analysis by CHD, non-significant associations were found in cases compared to controls. When stratified by control source, no significantly decreased risk was found in the additive model or dominant model. The present meta-analysis suggests that the TLR4 Asp299Gly polymorphism was not associated with decreased CHD risk in Caucasians.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900609	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/1414-431x20176306	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.50 n.9 2017	
Fonte: 	info:eu-repo/semantics/openAccess