Data/hora: 06/06/2024 01:01:27

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Human_Leishmaniasis@cytokines.bahia.br	
Autores: 	Barral-Netto,M.; Brodskyn,C.; Carvalho,E.M.; Barral,A.	
Data: 	1998-01-01	
Ano: 	1998	
Palavras-chave: 	Cytokines; Human leishmaniasis; Immunoregulation; IL-12; IL-10.	
Resumo: 	The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced production of or synergize with IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt;, and those cytokines that counterbalance its effects is fundamental for developing rational immunotherapeutic or immunoprophylactic approaches to leishmaniasis. Here we focus on the cytokine balance in human leishmaniasis, particularly IL-10 as an IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; opposing cytokine, and IL-12 as an IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; inducer. The effects of these cytokines were evaluated in terms of several parameters of the human immune response. IL-10 reduced lymphocyte proliferation, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; production and cytotoxic activity of responsive human peripheral blood mononuclear cells. Neutralization of IL-10 led to partial restoration of lymphoproliferation, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; production and cytotoxic activity in unresponsive visceral leishmaniasis patients. IL-12 also restored the responses of peripheral blood mononuclear cells from visceral leishmaniasis patients. The responses obtained with IL-12 are higher than those obtained with anti-IL-10, even when anti-IL-10 is combined with anti-IL-4	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100021	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X1998000100021	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.31 n.1 1998	
Fonte: 	info:eu-repo/semantics/openAccess