Data/hora: 09/06/2024 15:51:57

Provedor de dados: | 56
País: | Brazil
Título: | The rs878081 polymorphism of AIRE gene increases the risk of rheumatoid arthritis in a Chinese Han population: a case-control study
Autores: | Yang,Haoyu; Li,Jin; Jiang,Lifeng; Jiang,Xijia; Zhou,Xindie; Xu,Nanwei.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | AIRE; Single-nucleotide polymorphism; Rheumatoid arthritis; Case-control study.
Resumo: | The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid arthritis (RA) in different populations have yielded conflicting findings. Thus, this case-control study involving 300 RA cases and 300 controls was aimed to identify whether such association existed in a Chinese Han population from East China. The rs878081 polymorphism of the AIRE gene was genotyped. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using the chi-squared test, genetic model analysis, and stratification analysis. Genetic model analysis showed significant correlations between the TT genotype and the risk of RA (OR: 1.89, 95%CI: 1.03-3.47 in TT vs CC; OR: 1.84, 95%CI: 1.02-3.31 in TT vs CC+TC). Stratification analyses of sex, age, smoking, and alcoholism suggested that the rs878081 polymorphism of the AIRE gene increased RA risk among non-smokers. In conclusion, rs878081 polymorphism of AIRE gene increases the risk of RA in a Chinese Han population.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200612
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20187944
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.51 n.12 2018
Fonte: | info:eu-repo/semantics/openAccess