Data/hora: 01/06/2024 07:57:32

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Influence of He-Ne laser therapy on the dynamics of wound healing in mice treated with anti-inflammatory drugs	
Autores: 	Gonçalves,W.L.S.; Souza,F.M.; Conti,C.L.; Cirqueira,J.P.; Rocha,W.A.; Pires,J.G.P.; Barros,L.A.P.; Moysés,M.R.	
Data: 	2007-06-01	
Ano: 	2007	
Palavras-chave: 	Photo-stimulation; Skin; Collagen; Cyclooxygenase; Corticosteroids; Cicatrization; Anti-inflammatory drugs.	
Resumo: 	We determined the effects of helium-neon (He-Ne) laser irradiation on wound healing dynamics in mice treated with steroidal and non-steroidal anti-inflammatory agents. Male albino mice, 28-32 g, were randomized into 6 groups of 6 animals each: control (C), He-Ne laser (L), dexamethasone (D), D + L, celecoxib (X), and X + L. D and X were injected im at doses of 5 and 22 mg/kg, respectively, 24 h before the experiment. A 1-cm long surgical wound was made with a scalpel on the abdomens of the mice. Animals from groups L, D + L and X + L were exposed to 4 J (cm²)-1 day-1 of He-Ne laser for 12 s and were sacrificed on days 1, 2, or 3 after the procedure, when skin samples were taken for histological examination. A significant increase of collagen synthesis was observed in group L compared with C (168 ± 20 vs 63 ± 8 mm²). The basal cellularity values on day 1 were: C = 763 ± 47, L = 1116 ± 85, D = 376 ± 24, D + L = 698 ± 31, X = 453 ± 29, X + L = 639 ± 32 U/mm². These data show that application of L increases while D and X decrease the inflammatory cellularity compared with C. They also show that L restores the diminished cellularity induced by the anti-inflammatory drugs. We suggest that He-Ne laser promotes collagen formation and restores the baseline cellularity after pharmacological inhibition, indicating new perspectives for laser therapy aiming to increase the healing process when anti-inflammatory drugs are used.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600018	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2007000600018	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.40 n.6 2007	
Fonte: 	info:eu-repo/semantics/openAccess