Data/hora: 06/06/2024 00:47:20

Provedor de dados: | 56
País: | Brazil
Título: | Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models
Autores: | Del-Bel,E.A.; Oliveira,P.R.; Oliveira,J.A.C.; Mishra,P.K.; Jobe,P.C.; Garcia-Cairasco,N.
Data: | 1997-08-01
Ano: | 1997
Palavras-chave: | Experimental epilepsy; Seizures; Forebrain; Brainstem; Pilocarpine; Pentylenetetrazol; Audiogenic seizures; Genetically epilepsy-prone rats; GEPR; Nitric oxide.
Resumo: | The effect of acute (120 mg/kg) and chronic (25 mg/kg, twice a day, for 4 days) intraperitonial injection of the nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) was evaluated on seizure induction by drugs such as pilocarpine and pentylenetetrazole (PTZ) and by sound stimulation of audiogenic seizure-resistant (R) and audiogenic seizure-susceptible (S) rats. Seizures were elicited by a subconvulsant dose of pilocarpine (100 mg/kg) only after NOS inhibition. NOS inhibition also simultaneously potentiated the severity of PTZ-induced limbic seizures (60 mg/kg) and protected against PTZ-induced tonic seizures (80 mg/kg). The audiogenic seizure susceptibility of S or R rats did not change after similar treatments. In conclusion, proconvulsant effects of NOS inhibition are suggested to occur in the pilocarpine model and in the limbic components of PTZ-induced seizures, while an anticonvulsant role is suggested for the tonic seizures induced by higher doses of PTZ, revealing inhibitor-specific interactions with convulsant dose and also confirming the hypothesis that the effects of NOS inhibitors vary with the model of seizure
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800010
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997000800010
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.8 1997
Fonte: | info:eu-repo/semantics/openAccess