Data/hora: 05/06/2024 07:40:57

Provedor de dados: | 56
País: | Brazil
Título: | Variations in gastric compliance induced by acute blood volume changes in anesthetized rats
Autores: | Graça,J.R.V.; Leal,P.R.L.; Gondim,F.A.A.; Rola,F.H.; Santos,A.A.
Data: | 2002-03-01
Ano: | 2002
Palavras-chave: | Blood volume; Gastric compliance; Gastrointestinal motility; Hemorrhage; Hypervolemia.
Resumo: | The impact of acute volume imbalances on gastric volume (GV) was studied in anesthetized rats (250-300 g). After cervical and femoral vessel cannulation, a balloon catheter was positioned in the proximal stomach. The opposite end of the catheter was connected to a barostat with an electronic sensor coupled to a plethysmometer. A standard ionic solution was used to fill the balloon (about 3.0 ml) and the communicating vessel system, and to raise the reservoir liquid level 4 cm above the animals' xiphoid appendix. Due to constant barostat pressure, GV values were considered to represent the gastric compliance index. All animals were monitored for 90 min. After a basal interval, they were randomly assigned to normovolemic, hypervolemic, hypovolemic or restored protocols. Data were compared by ANOVA followed by Bonferroni's test. Mean arterial pressure (MAP), central venous pressure (CVP) and GV values did not change in normovolemic animals (N = 5). Hypervolemic animals (N = 12) were transfused at 0.5 ml/min with a suspension of red blood cells in Ringer-lactate solution with albumin (12.5 ml/kg), which reduced GV values by 11.3% (P&lt;0.05). Hypovolemic rats (N = 12) were bled up to 10 ml/kg, a procedure that increased GV values by 15.8% (P&lt;0.05). In the restored group (N = 12), shed blood replacement brought GV values back to basal levels in bled animals (P&gt;0.05). MAP and CVP values increased (P&lt;0.05) after hypervolemia but decreased (P&lt;0.05) with hypovolemia. In conclusion, blood volume level modulates gastric compliance, turning the stomach into an adjustable reservoir, which could be part of the homeostatic process to balance blood volume.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300018
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2002000300018
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.35 n.3 2002
Fonte: | info:eu-repo/semantics/openAccess