Data/hora: 01/06/2024 08:10:33

Provedor de dados: | 56
País: | Brazil
Título: | Enhanced external counterpulsation improves cardiac function in Beagles after cardiopulmonary resuscitation
Autores: | Xiong,Jing; Zhang,Wei; Wei,Hongyan; Li,Xin; Dai,Gang; Hu,Chunlin.
Data: | 2020-01-01
Ano: | 2020
Palavras-chave: | Cardiopulmonary resuscitation; Hemodynamics; Enhanced external counterpulsation; PiCCO2; Myocardial blood flow; Beagle dog.
Resumo: | The aim of this study was to investigate the influence of enhanced external counterpulsation (EECP) on the cardiac function of beagle dogs after prolonged ventricular fibrillation. Twenty-four adult male beagles were randomly divided into control and EECP groups. Ventricular fibrillation was induced in the animals for 12 min, followed by 2 min of cardiopulmonary resuscitation. They then received EECP therapy for 4 h (EECP group) or not (control group). The hemodynamics was monitored using the PiCCO2 system. Blood gas and hemorheology were assessed at baseline and at 1, 2, and 4 h after return of spontaneous circulation (ROSC). The myocardial blood flow (MBF) was quantified by 18F-flurpiridaz PET myocardial perfusion imaging at baseline and 4 h after ROSC. Survival time of the animals was recorded within 24 h. Ventricular fibrillation was successfully induced in all animals, and they achieved ROSC after cardiopulmonary resuscitation. Survival time of the control group was shorter than that of the EECP group [median of 8 h (min 8 h, max 21 h) vs median of 24 h (min 16 h, max 24 h) (Kaplan Meyer plot analysis, P=0.0152). EECP improved blood gas analysis findings and increased the coronary perfusion pressure and MBF value. EECP also improved the cardiac function of Beagles after ROSC in multiple aspects, significantly increased blood flow velocity, and decreased plasma viscosity, erythrocyte aggregation index, and hematocrit levels. EECP improved the hemodynamics of beagle dogs and increased MBF, subsequently improving cardiac function and ultimately improving the survival time of animals after ROSC.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000100609
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20199136
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.53 n.1 2020
Fonte: | info:eu-repo/semantics/openAccess