Data/hora: 07/06/2024 07:20:38

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH	
Autores: 	Armelin,H.A.; Lotfi,C.F.P.	
Data: 	1999-07-01	
Ano: 	1999	
Palavras-chave: 	Adrenocortical cell cycle; ACTH; FGF2; ERK-MAPK; C-fos proto-oncogene.	
Resumo: 	FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700007	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X1999000700007	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.32 n.7 1999	
Fonte: 	info:eu-repo/semantics/openAccess