Data/hora: 09/06/2024 05:38:12

Provedor de dados: | 56
País: | Brazil
Título: | Localization of NMDA receptors in the cerebral cortex: a schematic overview
Data: | 1997-05-01
Ano: | 1997
Palavras-chave: | Glutamate; Ionotropic receptors; Autoreceptors; Heteroreceptors; Astrocytes; Neuron-glia signaling.
Resumo: | The fundamental role of N-methyl-D-aspartate (NMDA) receptors in many cortical functions has been firmly defined, as has its involvement in a number of neurological and psychiatric diseases. However, until recently very little was known about the anatomical localization of NMDA receptors in the cerebral cortex of mammals. The recent application of molecular biological techniques to the study of NMDA receptors has provided specific tools which have greatly expanded our understanding of the localization of NMDA receptors in the cerebral cortex. In particular, immunocytochemical studies on the distribution of cortical NMDA receptors have shown that NMDA receptors are preferentially localized on dendritic spines, have disclosed an unknown fraction of presynaptic NMDA receptors on both excitatory and inhibitory axon terminals, and demonstrated that cortical astrocytes do express NMDA receptors. These studies suggest that the effects induced by the activation of NMDA receptors are not due solely to the opening of NMDA channels on neuronal postsynaptic membranes, as previously assumed, but that the activation of presynaptic and glial NMDA receptors may mediate part of these effects
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000500001
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997000500001
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.5 1997
Fonte: | info:eu-repo/semantics/openAccess