Data/hora: 11/06/2024 03:34:41

Provedor de dados: | 56
País: | Brazil
Título: | Plasma amino acids in pregnancy, placental intervillous space and preterm newborn infants
Autores: | Camelo Jr.,J.S.; Martinez,F.E.; Gonçalves,A.L.; Monteiro,J.P.; Jorge,S.M.
Data: | 2007-07-01
Ano: | 2007
Palavras-chave: | Amino acid analysis; Placenta; Umbilical cord; Intervillous space; Maternal venous blood; Premature infants.
Resumo: | Plasma amino acid levels have never been studied in the placental intervillous space of preterm gestations. Our objective was to determine the possible relationship between plasma amino acids of maternal venous blood (M), of the placental intervillous space (PIVS) and of the umbilical vein (UV) of preterm newborn infants. Plasma amino acid levels were analyzed by ion-exchange chromatography in M from 14 parturients and in the PIVS and UV of their preterm newborn infants. Mean gestational age was 34 ± 2 weeks, weight = 1827 ± 510 g, and all newborns were considered adequate for gestational age. The mean Apgar score was 8 and 9 at the first and fifth minutes. Plasma amino acid values were significantly lower in M than in PIVS (166%), except for aminobutyric acid. On average, plasma amino acid levels were significantly higher in UV than in M (107%) and were closer to PIVS than to M values, except for cystine and aminobutyric acid (P &lt; 0.05). Comparison of the mean plasma amino acid concentrations in the UV of preterm to those of term newborn infants previously studied by our group showed no significant difference, except for proline (P &lt; 0.05), preterm &gt; term. These data suggest that the mechanisms of active amino acid transport are centralized in the syncytiotrophoblast, with their passage to the fetus being an active bidirectional process with asymmetric efflux. PIVS could be a reserve amino acid space for the protection of the fetal compartment from inadequate maternal amino acid variations.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700012
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2006005000103
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.40 n.7 2007
Fonte: | info:eu-repo/semantics/openAccess