Data/hora: 12/06/2024 01:47:20

Provedor de dados: | 56
País: | Brazil
Título: | Evidence of muscarinic acetylcholine receptors in the retinal centrifugal system of the chick
Autores: | Calaza,K.C.; Gardino,P.F.
Data: | 2000-09-01
Ano: | 2000
Palavras-chave: | Muscarinic receptors; Retina; Isthmo-optic nucleus; Centrifugal fibers; Acetylcholine; Chick.
Resumo: | In this study we characterize the presence of muscarinic acetylcholine receptors (mAChR) in the isthmo-optic nucleus (ION) of chicks by immunohistochemistry with the M35 antibody. Some M35-immunoreactive fibers were observed emerging from the retinal optic nerve insertion, suggesting that they could be centrifugal fibers. Indeed, intraocular injections of cholera toxin B (CTb), a retrograde tracer, and double-labeling with M35 and CTb in the ION confirmed this hypothesis. The presence of M35-immunoreactive cells and the possible mAChR expression in ION and ectopic neuron cells in the chick brain strongly suggest the existence of such a cholinergic system in this nucleus and that acetylcholine release from amacrine cells may mediate interactions between retinal cells and ION terminals.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900014
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000900014
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.9 2000
Fonte: | info:eu-repo/semantics/openAccess