Data/hora: 06/06/2024 14:01:06

Provedor de dados: | 56
País: | Brazil
Título: | Cytokines as determinants of disease and disease interactions
Autores: | Sher,A.; Gazzinelli,R.T.; Jankovic,D.; Scharton-Kersten,T.; Yap,G.; Doherty,T.M.; Wynn,T.
Data: | 1998-01-01
Ano: | 1998
Palavras-chave: | Cytokines disease immunopathology HIV-I parasites; Interleukin-10.
Resumo: | The immune response to pathogens results in both host resistance and immunopathology. Cytokines and in particular those lymphokines produced by Th1 and Th2 cells play a key role in determining the balance between these two immunologic outcomes. Recent data suggest that interleukin-10, a product of both Th2 cells and macrophages, protects the host against excessive immunopathology. The cytokine environment generated by different pathogens may also influence the course and outcome of infections with unrelated organisms. This relationship may be particularly important in the case of HIV-1 where prior Th1 or Th2 biases established by helminth or intracellular infections may influence either initial viral susceptibility or drive progression to AIDS through immune activation
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000100011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.1 1998
Fonte: | info:eu-repo/semantics/openAccess