Data/hora: 06/06/2024 10:41:35

Provedor de dados: | 56
País: | Brazil
Título: | Factors associated with penicillin-nonsusceptible pneumococcal infections in Brazil
Autores: | Levin,A.S.; Sessegolo,J.F.; Teixeira,L.M.; Barone,A.A.
Data: | 2003-06-01
Ano: | 2003
Palavras-chave: | Streptococcus pneumoniae; Penicillin susceptibility; Risk factors; Prevalence study.
Resumo: | Resistance of Streptococcus pneumoniae is a worldwide, growing problem. Studies of factors associated with resistance to penicillin have not been conducted in Brazil. The objective of the present study was to evaluate factors associated with infection by S. pneumoniae not susceptible to penicillin. A prevalence study was conducted including all patients with a positive culture for S. pneumoniae in a hospital from July 1991 to December 1992 and the year 1994. Of 165 patients identified, 139 were considered to have clinically relevant infections and 88% of them had invasive infections. All infections were community acquired and consisted of pneumonia (44%) and of central nervous system (19%), pelvic or abdominal (12%), upper airway or ocular (12%), primary bloodstream (9%) and skin and soft tissue (5%) infections. Mortality was 25%. Susceptibility to penicillin was present in 77.6% of the isolates; 21.8% were relatively resistant, and one isolate was resistant (minimal inhibitory concentration = 4 µg/ml). Multivariate analysis showed that age below 4 years (odds ratio (OR): 3.53, 95% confidence interval (95%CI): 1.39-8.96) and renal failure (OR: 5.50, 95%CI: 1.07-28.36) were associated with lack of susceptibility to penicillin. Bacteremia occurred significantly less frequently in penicillin-nonsusceptible infections (OR: 0.34, 95%CI: 0.14-0.84), possibly suggesting that lack of penicillin susceptibility is associated with lower virulence in S. pneumoniae.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000600017
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2003000600017
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.36 n.6 2003
Fonte: | info:eu-repo/semantics/openAccess