Data/hora: 05/06/2024 19:07:14

Provedor de dados: | 56
País: | Brazil
Título: | Paradoxical sleep deprivation increases plasma endothelin levels
Autores: | Palma,B.D.; Gabriel Jr.,A.; Bignotto,M.; Tufik,S.
Data: | 2002-01-01
Ano: | 2002
Palavras-chave: | Endothelin; Sleep deprivation; Rat; Hypertension.
Resumo: | The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA). OSA patients exhibit repetitive episodes of apnea and hypopnea that result in hypoxia and consecutive arousals. These patients are chronically sleep deprived, which may aggravate the hypertensive features, since literature data show that sleep deprivation results in hypertension both in humans and in animals. Based on the reported relationship between ET-1, hypertension and sleep deprivation consequences, the purpose of the present study was to determine plasma ET concentrations in paradoxical sleep-deprived animals. Male Wistar rats, 3 to 4 months old (N = 10 per group), were deprived of sleep for 24 and 96 h by the platform technique and plasma ET-1/2 was measured by radioimmunoassay. Analysis of plasma revealed that 96 h of sleep deprivation induced a significant increase in ET-1/2 release (6.58 fmol/ml) compared to control (5.07 fmol/ml). These data show that sleep deprivation altered plasma ET-1/2 concentrations, suggesting that such an increase may participate in the genesis of arterial hypertension and cardiorespiratory changes observed after sleep deprivation.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2002000100011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.35 n.1 2002
Fonte: | info:eu-repo/semantics/openAccess