Data/hora: 10/06/2024 08:13:13

Provedor de dados: | 56
País: | Brazil
Título: | Genetic alterations in head and neck squamous cell carcinomas
Autores: | Nagai,M.A.
Data: | 1999-07-01
Ano: | 1999
Palavras-chave: | Genetic alterations; Oncogene; Tumor suppressor gene; Head and neck cancer.
Resumo: | The genetic alterations observed in head and neck cancer are mainly due to oncogene activation (gain of function mutations) and tumor suppressor gene inactivation (loss of function mutations), leading to deregulation of cell proliferation and death. These genetic alterations include gene amplification and overexpression of oncogenes such as myc, erbB-2, EGFR and cyclinD1 and mutations, deletions and hypermethylation leading to p16 and TP53 tumor suppressor gene inactivation. In addition, loss of heterozygosity in several chromosomal regions is frequently observed, suggesting that other tumor suppressor genes not yet identified could be involved in the tumorigenic process of head and neck cancers. The exact temporal sequence of the genetic alterations during head and neck squamous cell carcinoma (HNSCC) development and progression has not yet been defined and their diagnostic or prognostic significance is controversial. Advances in the understanding of the molecular basis of head and neck cancer should help in the identification of new markers that could be used for the diagnosis, prognosis and treatment of the disease.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700015
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1999000700015
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.32 n.7 1999
Fonte: | info:eu-repo/semantics/openAccess