Data/hora: 01/06/2024 02:48:45

Provedor de dados: | 56
País: | Brazil
Título: | Can calories from ethanol contribute to body weight preservation by malnourished rats?
Autores: | Aguiar,A.S.; Da-Silva,V.A.; Boaventura,G.T.
Data: | 2004-06-01
Ano: | 2004
Palavras-chave: | Ethanol; Weight gain; Malnutrition; Rats; Toxicity.
Resumo: | Our objective was to compare the use of calories from ethanol by well-nourished and malnourished rats in terms of body weight. Female Wistar rats weighing 170-180 g at the beginning of the study were used. The animals were divided into two groups (N = 12 each): group W received water ad libitum and group E an ethanol solution ad libitum as the only source of liquid throughout the experiment. The concentration of ethanol was increased weekly from 0 to 5, 10, 20 and 40% (v/v). In the well-nourished phase (A), all rats received food ad libitum (AW and AE). Ethanol treatment (AE) was then interrupted and water was offered to both groups. After 2 weeks both AW and AE rats were submitted to food restriction (50% of group AW food consumption), thus initiating the malnutrition phase (M). Liquid was offered as described before to the same W (MW) and E (ME) groups. The weight gain during the 1-week treatment of AE rats was similar to that of AW animals only when AE rats received the 5% (v/v) ethanol solution (9.16 vs 10.47 g). Weight loss was observed after exposure to 10% ethanol (P &lt; 0.05) in spite of maintenance of caloric intake. Malnourished rats presented weight loss, which was attenuated by ethanol intake up to the 20% (v/v) solution and was related to an increased caloric offer. This effect was not observed with the 40% ethanol solution (-9.98 g). These data suggest that calories from ethanol were used to maintain body weight up to the concentration of 10% (v/v) (well-nourished) and 20% (v/v) (malnourished) and that ethanol has a toxic profile which depends on nutritional status.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600009
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2004000600009
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.37 n.6 2004
Fonte: | info:eu-repo/semantics/openAccess