Data/hora: 02/06/2024 15:20:45

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Experimental models in vaccine research: malaria and leishmaniasis	
Autores: 	Teixeira,C.; Gomes,R.	
Data: 	2013-02-01	
Ano: 	2013	
Palavras-chave: 	Human vaccines; Animal models; Malaria; Leishmaniasis.	
Resumo: 	Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200109	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/1414-431X20122460	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.46 n.2 2013	
Fonte: 	info:eu-repo/semantics/openAccess