Data/hora: 06/06/2024 01:33:50

Provedor de dados: | 56
País: | Brazil
Título: | The role of nitric oxide in reproduction
Autores: | McCann,S.M.; Mastronardi,C.; Walczewska,A.; Karanth,S.; Rettori,V.; Yu,W.H.
Data: | 1999-11-01
Ano: | 1999
Palavras-chave: | NO and synthase; NG-monomethyl-L-arginine; Nitroprusside; NOergic neurons; FSH; LH; LHRH; FSHRF.
Resumo: | Nitric oxide (NO) plays a crucial role in reproduction at every level in the organism. In the brain, it activates the release of luteinizing hormone-releasing hormone (LHRH). The axons of the LHRH neurons project to the mating centers in the brain stem and by afferent pathways evoke the lordosis reflex in female rats. In males, there is activation of NOergic terminals that release NO in the corpora cavernosa penis to induce erection by generation of cyclic guanosine monophosphate (cGMP). NO also activates the release of LHRH which reaches the pituitary and activates the release of gonadotropins by activating neural NO synthase (nNOS) in the pituitary gland. In the gonad, NO plays an important role in inducing ovulation and in causing luteolysis, whereas in the reproductive tract, it relaxes uterine muscle via cGMP and constricts it via prostaglandins (PG).
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100007
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1999001100007
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.32 n.11 1999
Fonte: | info:eu-repo/semantics/openAccess