Data/hora: 15/06/2024 19:50:19

Provedor de dados: | 56
País: | Brazil
Título: | Origin and pathogenesis of antiphospholipid antibodies
Autores: | Celli,C.M.; Gharavi,A.E.
Data: | 1998-06-01
Ano: | 1998
Palavras-chave: | Antiphospholipid antibodies; Antiphospholipid syndrome; Systemic lupus erythematosus; Syphilis; Cardiolipin; Beta-2-glycoprotein I.
Resumo: | Antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies that are detected in the serum of patients with a variety of conditions, including autoimmune (systemic lupus erythematosus), infectious (syphilis, AIDS) and lymphoproliferative disorders (paraproteinemia, myeloma, lymphocytic leukemias). Thrombosis, thrombocytopenia, recurrent fetal loss and other clinical complications are currently associated with a subgroup of aPL designating the antiphospholipid syndrome. In contrast, aPL from patients with infectious disorders are not associated with any clinical manifestation. These findings led to increased interest in the origin and pathogenesis of aPL. Here we present the clinical features of the antiphospholipid syndrome and review the origin of aPL, the characteristics of experimentally induced aPL and their historical background. Within this context, we discuss the most probable pathogenic mechanisms induced by these antibodies.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000600002
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000600002
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.6 1998
Fonte: | info:eu-repo/semantics/openAccess