Data/hora: 02/06/2024 15:38:27

Provedor de dados: | 56
País: | Brazil
Título: | Ziyuglycoside II-induced apoptosis in human gastric carcinoma BGC-823 cells by regulating Bax/Bcl-2 expression and activating caspase-3 pathway
Autores: | Zhu,A.K.; Zhou,H.; Xia,J.Z.; Jin,H.C.; Wang,K.; Yan,J.; Zuo,J.B.; Zhu,X.; Shan,T.
Data: | 2013-08-01
Ano: | 2013
Palavras-chave: | Ziyuglycoside II; BGC-823 cells; Apoptosis; Bax/Bcl-2; Caspase-3.
Resumo: | Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties. We report here on the anticancer effect of ziyuglycoside II on human gastric carcinoma BGC-823 cells. We investigated the effects of ziyuglycoside II on cell growth, cell cycle, and cell apoptosis of this cell line. Our results revealed that ziyuglycoside II could inhibit the proliferation of BGC-823 cells by inducing apoptosis but not cell cycle arrest, which was associated with regulation of Bax/Bcl-2 expression, and activation of the caspase-3 pathway. Our study is the first to report the antitumor potential of ziyuglycoside II in BGC-823 gastric cancer cells. Ziyuglycoside II may become a potential therapeutic agent against gastric cancer in the future.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000800670
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20133050
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.46 n.8 2013
Fonte: | info:eu-repo/semantics/openAccess