Data/hora: 05/06/2024 18:06:07

Provedor de dados: | 56
País: | Brazil
Título: | Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
Autores: | Chen,Jie; Wu,Yu; Yu,Jiannong; Shen,Jinming.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | TNF-α; Osteoarthritis; Polymorphism; Meta-analysis.
Resumo: | Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populations, we conducted a hospital-based case-control study involving 257 knee OA patients and 305 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan™ kit. Our study indicated that the AA genotype of TNF-α rs1800629 polymorphism was associated with increased risk of OA. Subsequently, we conducted a meta-analysis and found that rs1800629 polymorphism increased the risk of OA in the recessive and homozygous models. Stratification analysis of ethnicity also obtained a significant association among Asian populations. In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians. Larger studies with more diverse ethnic populations are needed to confirm these results.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800604
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20187311
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.51 n.8 2018
Fonte: | info:eu-repo/semantics/openAccess