Data/hora: 06/06/2024 03:35:38

Provedor de dados: | 56
País: | Brazil
Título: | Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts
Autores: | Schwartzmann-Solon,A.M.; Visconti,M.A.; Castrucci,A.M.L.
Data: | 1998-12-01
Ano: | 1998
Palavras-chave: | Vulgar vitiligo &lt; FONT FACE=Symbol&gt; A&lt; /FONT&gt; -MSH synthetic analogue minigrafting.
Resumo: | Human subjects with active vulgar vitiligo do not respond well to autologous dermo-epidermal minigrafting. Eighteen subjects were treated with the &lt;FONT FACE="Symbol"&gt;a&lt;/FONT&gt;-melanocyte-stimulating hormone (&lt;FONT FACE="Symbol"&gt;a&lt;/FONT&gt;-MSH) synthetic analogue &amp;amp;#091;Nle4, D-Phe7&amp;amp;#093;-&lt;FONT FACE="Symbol"&gt;a&lt;/FONT&gt;-MSH. The hormone (50 µl, 0.4 mM) was applied topically to 30-cm2 lesions in which 29-48 minigrafts had been made. The hormone did not improve the success of the minigrafting and no differences were observed in local or distant repigmentation in treated subjects as compared to the placebo group. Aliquots of 24-h urine concentrated by lyophilization irreversibly darkened toad skins, demonstrating the presence of the analogue. This is the first report of the transdermal delivery of a topically applied melanotropin in living human subjects.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200008
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998001200008
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.12 1998
Fonte: | info:eu-repo/semantics/openAccess