Data/hora: 08/06/2024 16:21:45

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Poly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system	
Autores: 	Lima,K.M.; Rodrigues Júnior,J.M.	
Data: 	1999-02-01	
Ano: 	1999	
Palavras-chave: 	Vaccine; Adjuvant; Microspheres; Microencapsulation; Biomaterial.	
Resumo: 	Successful vaccine application means maximum protection with minimal number of administrations. A rational development of vaccines involves studies of the nature of the antigen as well as of the adjuvant to be used to improve the immune responses. This has provided the impetus for studies to design the degradable devices and for different approaches to antigen delivery by different routes of administration. The development of controlled release systems based on polymeric devices that permit a sustained or pulsed release of encapsulated antigens has attracted much interest. Polymeric delivery systems consist of polymers that release their content continuously in a controlled manner over a period of time. The development of a biocompatible delivery system for parenteral administration offers several advantages in terms of immunoadjuvanticity over other compounds. It was found that, in contrast to other carriers, microspheres are more stable, thus permitting administration by the oral or parenteral route. In the present study, we describe the main characteristics and potentialities of this new immunoadjuvant for oral and parenteral administration.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200005	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X1999000200005	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.32 n.2 1999	
Fonte: 	info:eu-repo/semantics/openAccess