Data/hora: 01/06/2024 02:52:24

Provedor de dados: | 56
País: | Brazil
Título: | Cyclophosphamide in the treatment of focal segmental glomerulosclerosis
Autores: | Martinelli,R.; Pereira,L.J.; Silva,O.M.M.; Okumura,A.S.; Rocha,H.
Data: | 2004-09-01
Ano: | 2004
Palavras-chave: | Cyclophosphamide; Prednisone; Nephrotic syndrome; Primary glomerular disease; Focal segmental glomerulosclerosis.
Resumo: | Prednisone is the initial treatment of primary focal segmental glomerulosclerosis. However, when immunosuppressive agents in combination with steroids are used in the treatment of prednisone-dependent and prednisone-resistant patients the remission rate is variable. We report a long-term trial using cyclophosphamide (2.0 to 3.0 mg/kg body weight for 12 weeks) in combination with prednisone (1.0 to 2.0 mg/kg body weight), as compared with prednisone alone for the treatment of prednisone-resistant and frequently relapsing nephrotic syndrome and focal segmental glomerulosclerosis. Fifty-four patients (34 males and 20 females) with a diagnosis of idiopathic nephrotic syndrome and focal segmental glomerulosclerosis, followed-up for an average of 86.1 ± 82.4 months, were evaluated. Complete remission occurred in 20.4% and partial remission in 14.8% of the patients treated with steroids and in 26.7 and 20.0% of the patients treated with cyclophosphamide + prednisone, respectively. Of the 24 prednisone-resistant patients treated with steroids in combination with cyclophosphamide, 33.3% obtained a complete/partial response. At the time of final evaluation, 25% of the patients treated with prednisone and 10.0% of those treated with prednisone in combination with cyclophosphamide had reached end-stage renal disease. Persistent nephrotic syndrome and progressive renal insufficiency were more frequently observed among the patients treated with prednisone alone (50.0 vs 33.3% and 33.3 vs 16.7%, respectively). The treatments were well tolerated and no patient experienced adverse reactions requiring discontinuation of medications. Although open-label and non-randomized, the present trial showed that cyclophosphamide is a reasonable choice for the treatment of primary focal segmental glomerulosclerosis and prednisone-resistant nephrotic syndrome.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000900011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2004000900011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.37 n.9 2004
Fonte: | info:eu-repo/semantics/openAccess