Data/hora: 11/06/2024 13:56:09

Provedor de dados: | 56
País: | Brazil
Título: | The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice
Autores: | Tristão,F.S.M.; Rocha,F.A.; Dias,F.C.; Rossi,M.A.; Silva,J.S.
Data: | 2013-10-01
Ano: | 2013
Palavras-chave: | Lung; Paracoccidioidomycosis; Paracoccidioides brasiliensis.
Resumo: | Paracoccidioidomycosis (PCM) is a chronic systemic mycosis caused by the inhalation of the thermally dimorphic fungus Paracoccidioides brasiliensis as well as the recently described P. lutzii. Because the primary infection occurs in the lungs, we investigated the differential involvement of the right and left lungs in experimental P. brasiliensis infection. Lungs were collected from C57BL/6 mice at 70 days after intravenous infection with 1×106 yeast cells of a virulent strain of P. brasiliensis (Pb18). The left lung, which in mice is smaller and has fewer lobes than the right lung, yielded increased fungal recovery associated with a predominant interleukin-4 response and diminished synthesis of interferon-γ and nitric oxide compared with the right lung. Our data indicate differential involvement of the right and left lungs during experimental PCM. This knowledge emphasizes the need for an accurate, standardized protocol for tissue collection during studies of experimental P. brasiliensis infection, since experiments using the same lungs favor the collection of comparable data among different mice.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000839
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20133140
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.46 n.10 2013
Fonte: | info:eu-repo/semantics/openAccess