Data/hora: 09/06/2024 10:57:53

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells	
Autores: 	Xiao,Y.-J.; Diao,Q.-C.; Liang,Y.-H.; Zeng,K.	
Data: 	2017-01-01	
Ano: 	2017	
Palavras-chave: 	Schiff bases; Coordination compound; Antitumor activity.	
Resumo: 	Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structural analysis revealed that compounds 1 and 2 are both six-coordinate in a distorted octahedral geometry, and the 1D chain structure was formed by the π…π and C-H…O interactions or C-H…Cl interaction. The in vitro antitumor activities of 1, 2 and their corresponding organic ligands Py, L1, and L2 were studied and evaluated, in which three human skin cancer cell lines (A-431, HT-144 and SK-MEL-30) were used in the screening tests.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700607	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/1414-431x20176390	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.50 n.7 2017	
Fonte: 	info:eu-repo/semantics/openAccess