Data/hora: 06/06/2024 02:38:25

Provedor de dados: | 56
País: | Brazil
Título: | Elevated levels of plasma osteoprotegerin are associated with all-cause mortality risk and atherosclerosis in patients with stages 3 to 5 chronic kidney disease
Autores: | Nascimento,M.M.; Hayashi,S.Y.; Riella,M.C.; Lindholm,B.
Data: | 2014-11-01
Ano: | 2014
Palavras-chave: | Atherosclerosis; Chronic kidney disease; Inflammation; Mortality; Osteoprotegerin.
Resumo: | Osteoprotegerin (OPG) regulates bone mass by inhibiting osteoclast differentiation and activation, and plays a role in vascular calcification. We evaluated the relationship between osteoprotegerin levels and inflammatory markers, atherosclerosis, and mortality in patients with stages 3-5 chronic kidney disease. A total of 145 subjects (median age 61 years, 61% men; 36 patients on hemodialysis, 55 patients on peritoneal dialysis, and 54 patients with stages 3-5 chronic kidney disease) were studied. Clinical characteristics, markers of mineral metabolism (including fibroblast growth factor-23 [FGF-23]) and inflammation (high-sensitivity C-reactive protein [hsCRP] and interleukin-6 [IL-6]), and the intima-media thickness (IMT) in the common carotid arteries were measured at baseline. Cardiac function was assessed by color tissue Doppler echocardiography. After 36 months follow-up, the survival rate by Kaplan-Meier analysis was significantly different according to OPG levels (χ2=14.33; P=0.002). Increased OPG levels were positively associated with IL-6 (r=0.38, P&lt;0.001), FGF-23 (r=0.26, P&lt;0.001) and hsCRP (r=0.0.24, P=0.003). In addition, OPG was positively associated with troponin I (r=0.54, P&lt;0.001) and IMT (r=0.39, P&lt;0.0001). Finally, in Cox analysis, only OPG (HR=1.07, 95%CI=1.02-1.13) and hsCRP (HR=1.02, 95%CI=1.01-1.04) were independently associated with increased risk of death. These results suggested that elevated levels of serum OPG might be associated with atherosclerosis and all-cause mortality in patients with chronic kidney disease.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100995
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20144007
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.47 n.11 2014
Fonte: | info:eu-repo/semantics/openAccess