Data/hora: 02/06/2024 17:56:56

Provedor de dados: | 56
País: | Brazil
Título: | Transgenic animal models for the functional analysis of vasoactive peptides
Autores: | Bader,M.
Data: | 1998-09-01
Ano: | 1998
Palavras-chave: | Renin-angiotensin system; Transgenic; Animal models; Knockout.
Resumo: | The interplay of vasoactive peptide systems is an essential determinant of blood pressure regulation in mammals. While the endothelin and the renin-angiotensin systems raise blood pressure by inducing vasoconstriction and sodium retention, the kallikrein-kinin and the natriuretic-peptide systems reduce arterial pressure by eliciting vasodilatation and natriuresis. Transgenic technology has proven to be very useful for the functional analysis of vasoactive peptide systems. As an outstanding example, transgenic rats overexpressing the mouse Ren-2 renin gene in several tissues become extremely hypertensive. Several other transgenic rat and mouse strains with genetic modifications of components of the renin-angiotensin system have been developed in the past decade. Moreover, in recent years gene-targeting technology was employed to produce mouse strains lacking these proteins. The established animal models as well as the main insights gained by their analysis are summarized in this review.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000900011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.9 1998
Fonte: | info:eu-repo/semantics/openAccess